Structure of PDB 7fa1 Chain A

Receptor sequence
>7fa1A (length=276) Species: 694009 (Severe acute respiratory syndrome-related coronavirus) [Search protein sequence]
AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYC
CRDHDHEIAWFTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSK
VKVIQPRVEKKKTEGFMGRIRSVYPVASPQECNNMHLSTLMKCNHCDEVS
WQTCDFLKATCEHCGTENLVIEGPTTCGYLPTNAVVKMPCPACQDPEIGP
EHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKRAYWVPRASAD
IGSGHTGITGDNVETLNEDLLEILSR
3D structure
PDB7fa1 Crystal Structure of N-terminus of the non-structural protein 2 from SARS coronavirus
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C144 C147 C162 C165 C143 C146 C161 C164
BS02 ZN A C191 C194 H203 C237 C190 C193 H202 C236
BS03 ZN A C21 C52 H55 H57 C20 C51 H54 H56
External links
PDB RCSB:7fa1, PDBe:7fa1, PDBj:7fa1
PDBsum7fa1
PubMed35729072
UniProtP0C6X7|R1AB_SARS Replicase polyprotein 1ab (Gene Name=rep)

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