Structure of PDB 7f8x Chain A

Receptor sequence
>7f8xA (length=443) Species: 9606,10665 [Search protein sequence]
KEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVS
DLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTWNLVAIS
LERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFT
KNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLEL
YQGINIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELD
KAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRA
ALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAK
RVITTFRTGTWDAYAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRA
YDTASAERRLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLG
3D structure
PDB7f8x Structures of the human cholecystokinin receptors bound to agonists and antagonists.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.17: lysozyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F97 P101 N102 M121 Y176 M195 C196 R197 I563 F564 N567 R570 E578 L581 S582 I586 L590 F61 P65 N66 M85 Y140 M159 C160 R161 I392 F393 N396 R399 E407 L410 S411 I415 L419
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0004930 G protein-coupled receptor activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0016020 membrane
GO:0030430 host cell cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7f8x, PDBe:7f8x, PDBj:7f8x
PDBsum7f8x
PubMed34556863
UniProtP00720|ENLYS_BPT4 Endolysin (Gene Name=E);
P32238|CCKAR_HUMAN Cholecystokinin receptor type A (Gene Name=CCKAR)

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