Structure of PDB 7f8u Chain A

Receptor sequence
>7f8uA (length=438) Species: 9606,10665 [Search protein sequence]
KEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVS
NLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTWNLVAIS
LERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFT
KNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLEL
YQGINIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELD
KAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRA
ALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAK
RVITTFRTGTWDAYAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRA
YDTASAERRLSGTPISFILLLSYTSSCVNPIIYCFMNK
3D structure
PDB7f8u Structures of the human cholecystokinin receptors bound to agonists and antagonists.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.17: lysozyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1OE A M121 F330 N333 R336 A343 I352 M85 F393 N396 R399 A406 I415
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0004930 G protein-coupled receptor activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0016020 membrane
GO:0030430 host cell cytoplasm

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Cellular Component
External links
PDB RCSB:7f8u, PDBe:7f8u, PDBj:7f8u
PDBsum7f8u
PubMed34556863
UniProtP00720|ENLYS_BPT4 Endolysin (Gene Name=E);
P32238|CCKAR_HUMAN Cholecystokinin receptor type A (Gene Name=CCKAR)

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