Structure of PDB 7f8j Chain A

Receptor sequence
>7f8jA (length=320) Species: 9606 (Homo sapiens) [Search protein sequence]
AIAQLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLIS
LAFAQEISIGTQISCFSPSSFSWRQAAFVDSYCWAAVQQKNSLQSESGNL
PLWLHKFFPYILLLFAILLYLPPLFWRFAAAPHICSDLKFIMEELDKVYN
RAIKAAKPIVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIYLGYYFS
LSSLSDEFVCSIKSGILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVL
LAPVVVYTLFVPFRQKTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLFLE
ENISEVKSYKCLKVLENIKS
3D structure
PDB7f8j Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids.
ChainA
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LBN A M37 C40 I41 Y293 M36 C39 I40 Y257
BS02 LBN A F235 V282 L286 F199 V246 L250
BS03 LBN A F126 S215 L219 F125 S179 L183
BS04 LBN A L101 W104 Y111 I112 L100 W103 Y110 I111
BS05 LBN A K91 W104 K90 W103
BS06 LBN A L122 F129 L121 F128
Gene Ontology
Molecular Function
GO:0002020 protease binding
GO:0003779 actin binding
GO:0005102 signaling receptor binding
GO:0005198 structural molecule activity
GO:0005243 gap junction channel activity
GO:0005253 monoatomic anion channel activity
GO:0005262 calcium channel activity
GO:0005347 ATP transmembrane transporter activity
GO:0005515 protein binding
GO:0015267 channel activity
GO:0022829 wide pore channel activity
GO:0022840 leak channel activity
GO:0044325 transmembrane transporter binding
GO:0044877 protein-containing complex binding
GO:0051015 actin filament binding
GO:0055077 gap junction hemi-channel activity
GO:0097110 scaffold protein binding
Biological Process
GO:0002931 response to ischemia
GO:0006812 monoatomic cation transport
GO:0006816 calcium ion transport
GO:0007267 cell-cell signaling
GO:0015867 ATP transport
GO:0030154 cell differentiation
GO:0032730 positive regulation of interleukin-1 alpha production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032732 positive regulation of interleukin-1 production
GO:0033198 response to ATP
GO:0048477 oogenesis
GO:0060907 positive regulation of macrophage cytokine production
GO:0070588 calcium ion transmembrane transport
GO:0098656 monoatomic anion transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005921 gap junction
GO:0016020 membrane
GO:0032059 bleb
GO:0032991 protein-containing complex

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Cellular Component
External links
PDB RCSB:7f8j, PDBe:7f8j, PDBj:7f8j
PDBsum7f8j
PubMed35133866
UniProtQ96RD7|PANX1_HUMAN Pannexin-1 (Gene Name=PANX1)

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