Structure of PDB 7f7o Chain A

Receptor sequence
>7f7oA (length=325) Species: 9606 (Homo sapiens) [Search protein sequence]
HHMLHLLEQIRAYCETCWEWQEAHMPAPVEHQICPAVCVLMKLSFDEEHR
HAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDV
ANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTL
REVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGAL
AFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQ
TLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHS
KHKMIAMGSAAALRNLMANRPAKYK
3D structure
PDB7f7o The tracer of FP assay for screening APC-Asef inhbitors
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A M503 F510 G511 K516 Q542 V543 R549 N550 W553 S587 S590 W593 N594 A597 M90 F97 G98 K103 Q129 V130 R136 N137 W140 S174 S177 W180 N181 A184
BS02 4CI A K455 L456 F458 H462 K42 L43 F45 H49
Gene Ontology
Molecular Function
GO:0008013 beta-catenin binding
Biological Process
GO:0030178 negative regulation of Wnt signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:7f7o, PDBe:7f7o, PDBj:7f7o
PDBsum7f7o
PubMed
UniProtP25054|APC_HUMAN Adenomatous polyposis coli protein (Gene Name=APC)

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