Structure of PDB 7f7f Chain A

Receptor sequence
>7f7fA (length=1135) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
LRTVYYNMPLPKDMIDEEGNPIMQYPRNKINVYFLVLIILGAFQIFGVTN
PGLSAVPLVVIVIITAIKDAIEDSRRTVLDLEVNNTKTHILEGVENEDCK
FAKNYWKGVKVGDIVRIHNNDEIPADIILLSTSDTDGACYVETKNLDGET
NLKVRQSLKCTNTIRTSKDIARTKFWIESEGPHSNLYTYQGNMKWRNLAD
GEIRNEPITINNVLLRGCTLRNTKWAMGVVMFTGGDTKIMLNSGITPTKK
SRISRELNFSVVINFVLLFILCFVSGIANGVYYDKKGRSRFSYEFGTIAG
SAATNGFVSFWVAVILYQSLVPISLYISVEIIKTAQAAFIYGDVLLYNAK
LDYPCTPKSWNISDDLGQVEYIFSDKTGTLTQNVMEFKKCTINGVSYGRA
YTEALAGLRKRQGIDVETEGRREKAEIAKDRDTMIDELRALSGNSQFYPE
EVTFVSKGEVQQRCCEHFMLALALCHSVLVEANPDNPKKLDLKAQSPDEA
ALVATARDVGFSFVGKTKKGLIIEMQGIQKEFEILNILEFNSSRKRMSCI
VKIPGLNPGDEPRALLICKGADSIIYSRLSRQSGSNSEAILEKTALHLEQ
YATEGLRTLCIAQRELSWSEYEKWNEKYDIAAASLANREDELEVVADSIE
RELILLGGTAIEDRLQDGVPDCIELLAEAGIKLWVLTGDKVETAINIGFS
CNLLNNEMELLVIKTTGDDVKEFGSEPSEIVDALLSKYLKEYFNLTGSEE
EIFEAKKDHEFPKGNYAIVIDGDALKLALYGEDIRRKFLLLCKNCRAVLC
CRVSPSQKAAVVKLVKDSLDVMTLAIGDGSNDVAMIQSADVGIGIAGEEG
RQAVMCSDYAIGQFRYLARLVLVHGRWSYKRLAEMIPEFFYKNMIFALAL
FWYGIYNDFDGSYLYEYTYMMFYNLAFTSLPVIFLGILDQDVNDTISLVV
PQLYRVGILRKEWNQRKFLWYMLDGLYQSIICFFFPYLVYHKNMIVTSNG
LGLDHRYFVGVYVTTIAVISCNTYVLLHQYRWDWFSGLFIALSCLVVFAW
TGIWSSAIASREFFKAAARIYGAPSFWAVFFVAVLFCLLPRFTYDSFQKF
FYPTDVEIVREMWQHGHFDHYPPGYDPTDPNRPKV
3D structure
PDB7f7f Conformational changes of a phosphatidylcholine flippase in lipid membranes.
ChainA
Resolution3.81 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.6.2.1: P-type phospholipid transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D667 T669 D375 T377
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0090554 phosphatidylcholine floppase activity
GO:0090555 phosphatidylethanolamine flippase activity
GO:0090556 phosphatidylserine floppase activity
GO:0140326 ATPase-coupled intramembrane lipid transporter activity
GO:0140345 phosphatidylcholine flippase activity
GO:0140346 phosphatidylserine flippase activity
GO:0140351 glycosylceramide flippase activity
Biological Process
GO:0006869 lipid transport
GO:0006886 intracellular protein transport
GO:0006897 endocytosis
GO:0007163 establishment or maintenance of cell polarity
GO:0015914 phospholipid transport
GO:0045332 phospholipid translocation
GO:0099040 ceramide translocation
GO:0140331 aminophospholipid translocation
Cellular Component
GO:0005739 mitochondrion
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005933 cellular bud
GO:0005935 cellular bud neck
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0030428 cell septum
GO:0070867 mating projection tip membrane
GO:0071944 cell periphery
GO:1990531 phospholipid-translocating ATPase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7f7f, PDBe:7f7f, PDBj:7f7f
PDBsum7f7f
PubMed35294892
UniProtP32660|ATC5_YEAST Phospholipid-transporting ATPase DNF1 (Gene Name=DNF1)

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