Structure of PDB 7f6m Chain A

Receptor sequence
>7f6mA (length=341) Species: 9606 (Homo sapiens) [Search protein sequence]
GHHHHHHMLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICP
AVCVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLR
RYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVL
RNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAH
CTENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIAT
NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEAL
WDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYKD
3D structure
PDB7f6m Discovery of Efficient Adenomatous Polyposis Coli - Rho Guanine Nucleotide Exchange Factor 4 Inhibitors by Employing High Binding Affinity Tracer
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A M503 N507 F510 G511 K516 Q542 V543 R549 N550 W553 S590 W593 N594 N641 M105 N109 F112 G113 K118 Q144 V145 R151 N152 W155 S192 W195 N196 N243
Gene Ontology
Molecular Function
GO:0008013 beta-catenin binding
Biological Process
GO:0030178 negative regulation of Wnt signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:7f6m, PDBe:7f6m, PDBj:7f6m
PDBsum7f6m
PubMed
UniProtP25054|APC_HUMAN Adenomatous polyposis coli protein (Gene Name=APC)

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