Structure of PDB 7f65 Chain A

Receptor sequence
>7f65A (length=573) Species: 104109 (Rhodococcus sp. MB1 'Bresler 1999') [Search protein sequence]
VDGNYSVASNVMVPMRDGVRLAVDLYRPDADGPVPVLLVRNPYDKFDVFL
WSTQSTNWLEFVRDGYAVVIQDTRGLFASEGEFVPHVDDEADAEDTLSWI
LEQAWCDGNVGMFGKAYLGVTQWQAAVSGVGGLKAIAPSMASADLYRAPW
YGPGGALSVEALLGWSALIGRQLITSRSDARPEDAADFVQLAAILNDVAG
AASVTPLAEQPLLGRLIPWVIDQVVDHPDNDESWQSISLFERLGGLATPA
LITAGWYDGFVGESLRTFVAVKDNADARLVVGPWSHSNLTGRNADRKFGI
AATYPIQEATTMHKAFFDRHLRGETDALAGVPKVRLFVMGIDEWRDETDW
PLPDTAYTPFYLGGSGAANTSTGGGTLSTSISGTESADTYLYDPADPVPS
LGGTLLFHNGDNGPADQRPIHDRDDVLCYSTEVLTDPVEVTGTVSARLFV
SSSAVDTDFTAKLVDVFPDGRAIALCDGIVRMRYRETLVNPTLIEAGEIY
EVAIDMLATSNVFLPGHRIMVQVSSSNFPKYDRNSNTGGVIAREQLEEMC
TAVNRIHRGPEHPSHIVLPIIKR
3D structure
PDB7f65 Computational Design and Crystal Structure of a Highly Efficient Benzoylecgonine Hydrolase.
ChainA
Resolution2.202 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.1.84: cocaine esterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BEZ A Y44 A117 Y118 W151 W166 H287 Y43 A116 Y117 W150 W165 H286
Gene Ontology
Molecular Function
GO:0008239 dipeptidyl-peptidase activity
GO:0016787 hydrolase activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0050784 cocaine catabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7f65, PDBe:7f65, PDBj:7f65
PDBsum7f65
PubMed34351032
UniProtQ9L9D7|COCE_RHOSM Cocaine esterase (Gene Name=cocE)

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