Structure of PDB 7f51 Chain A

Receptor sequence
>7f51A (length=287) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
TEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLAR
LKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKD
VLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKS
KLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKI
TTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKA
NKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQ
3D structure
PDB7f51 Global profiling of regulatory elements in the histone benzoylation pathway.
ChainA
Resolution1.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C143 C146 C170 C173 C136 C139 C163 C166
BS02 BA7 A G32 A33 G34 F44 R45 F67 Q115 I117 H135 I181 F184 G223 T224 S225 V228 N248 L249 E250 Y269 S270 G25 A26 G27 F37 R38 F60 Q108 I110 H128 I174 F177 G216 T217 S218 V221 N241 L242 E243 Y262 S263
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:7f51, PDBe:7f51, PDBj:7f51
PDBsum7f51
PubMed35296687
UniProtP53686|HST2_YEAST NAD-dependent protein deacetylase HST2 (Gene Name=HST2)

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