Structure of PDB 7f4c Chain A

Receptor sequence
>7f4cA (length=300) Species: 273063 (Sulfurisphaera tokodaii str. 7) [Search protein sequence]
MKLLLFGYGNVGKAFRKLLHEKRSPELNDVIIGGIVTRRGIMLQDKEDFT
PDLEGDVFKAFEKIKPDIIVDVSSANYNNGEPSLSLYKEAIKDGVNIITT
NKAPLALAFNEIFSLARSKGVKIGFQGTVMSGTPSINLYRVLPGSRVIKI
RGILNGTTNFILTLMNKGVSFEEALKEAQRRGYAEEDPTLDINGFDAAAK
ITILANFMIGNSVTIKDVKFEGINRDLKIKLIAYADEKEVWVKPLPISQD
DPLYNVDGVENALEITTDIQSILIRGPGAGPVNAAYGALSDLILLKRDCL
3D structure
PDB7f4c Conformational changes in the catalytic region are responsible for heat-induced activation of hyperthermophilic homoserine dehydrogenase.
ChainA
Resolution1.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.1.1.3: homoserine dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A F6 G7 Y8 G9 N10 V11 T37 R38 R39 V72 S73 S74 T100 K102 G127 S131 E185 G284 A288 F6 G7 Y8 G9 N10 V11 T37 R38 R39 V72 S73 S74 T100 K102 G127 S131 E185 G280 A284
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004412 homoserine dehydrogenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0050661 NADP binding
Biological Process
GO:0006520 amino acid metabolic process
GO:0009086 methionine biosynthetic process
GO:0009088 threonine biosynthetic process
GO:0009090 homoserine biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7f4c, PDBe:7f4c, PDBj:7f4c
PDBsum7f4c
PubMed35835834
UniProtF9VNG5|DHOM_SULTO Homoserine dehydrogenase (Gene Name=hom)

[Back to BioLiP]