Structure of PDB 7f3m Chain A

Receptor sequence
>7f3mA (length=298) Species: 9606 (Homo sapiens) [Search protein sequence]
DLPLDPLWEFPRDRLVLGKPLGEGCGQVVRAEAFGMDPARPDQASTVAVK
MLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECA
AKGNLREFLRARRPPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLES
RKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKW
MAPEALFDEVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREG
HRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEE
3D structure
PDB7f3m Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors
ChainA
Resolution2.289 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GX3 A L473 E475 G476 C477 V481 A501 K503 E520 M524 V550 C552 A553 L619 A629 D630 L21 E23 G24 C25 V28 A48 K50 E67 M71 V97 C99 A100 L164 A174 D175 BindingDB: Ki=73nM,IC50=19nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7f3m, PDBe:7f3m, PDBj:7f3m
PDBsum7f3m
PubMed
UniProtP22455|FGFR4_HUMAN Fibroblast growth factor receptor 4 (Gene Name=FGFR4)

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