Structure of PDB 7f3g Chain A

Receptor sequence
>7f3gA (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
SEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSK
CRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFD
AITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDG
SKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGV
ITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELIT
MMLLVDVDQRFSAVQVLEHPWVN
3D structure
PDB7f3g Structural Basis of Inhibition of DCLK1 by Ruxolitinib.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RXT A G397 V404 A417 M465 V468 E515 N516 L518 G22 V29 A42 M90 V93 E140 N141 L143 BindingDB: Kd=68nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7f3g, PDBe:7f3g, PDBj:7f3g
PDBsum7f3g
PubMed34445192
UniProtO15075|DCLK1_HUMAN Serine/threonine-protein kinase DCLK1 (Gene Name=DCLK1)

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