Structure of PDB 7eyc Chain A

Receptor sequence

>7eycA (length=214) Species: 10090 (Mus musculus) [Search protein sequence]

QVQLQESGPGLVKPSQTLSLTCTVSGDSITSGYWNWIRQPPGKGLEYIGY
IRYSGRTYYNPSLKSRVTISRDTSKNQFSLKLSSVTAADTAVYYCASVYF
TYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPV
TVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTETYICNVNH
KPSNTKVDKKVEAA

3D structure

PDB

7eyc Monoclonal antibody Y01 prevents tauopathy progression induced by lysine 280-acetylated tau in cell and mouse models.

Chain

Resolution

2.49 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	Y33 N35 Y50 V95 Y96 F97	Y33 N35 Y50 V98 Y99 F100

External links

PDB	RCSB:7eyc, PDBe:7eyc, PDBj:7eyc
PDBsum	7eyc
PubMed	36917188

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