Structure of PDB 7ex4 Chain A

Receptor sequence

>7ex4A (length=181) Species: 1501396 (Ebinur lake virus) [Search protein sequence]

DPMYEQFLQRIQAVRTATVAKDISADILEARHDYFGRELCRALDIEYRNN
VLLDEIILDVYPGVNLMEYNVPHVTPDNYIWTGDMLLILDYKVSVGHDST
EVTYKKYTTLILPVMQEIGINTEICIIRANPVTNQISIVGEQFKRLFPTI
PVELNFARFFELRKMLLDKFADDEEFLMMIA

3D structure

PDB

7ex4 Structural and Biochemical Basis for Development of Diketo Acid Inhibitors Targeting the Cap-Snatching Endonuclease of the Ebinur Lake Virus (Order: Bunyavirales ).

Chain

Resolution

2.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.48: RNA-directed RNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	MN	A	N52 D79	N50 D77
BS02	MN	A	H34 D79 D92 Y93	H32 D77 D90 Y91
BS03	IA5	A	L30 E31 H34 N52 H75 D79 D92 Y93 K94	L28 E29 H32 N50 H73 D77 D90 Y91 K92

External links

PDB	RCSB:7ex4, PDBe:7ex4, PDBj:7ex4
PDBsum	7ex4
PubMed	35266805
UniProt	A0A059WLS9

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