Structure of PDB 7ewa Chain A

Receptor sequence
>7ewaA (length=169) Species: 9606 (Homo sapiens) [Search protein sequence]
GMTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGE
TCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQ
IKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTR
QGVDDAFYTLVREIRKHKE
3D structure
PDB7ewa KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A G13 G15 K16 S17 A18 F28 D30 N116 K117 D119 L120 S145 G14 G16 K17 S18 A19 F29 D31 N117 K118 D120 L121 S146
BS02 05F A D12 G60 E62 Y64 R68 D69 M72 D92 H95 Y96 Q99 I100 R102 V103 D13 G61 E63 Y65 R69 D70 M73 D93 H96 Y97 Q100 I101 R103 V104
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:7ewa, PDBe:7ewa, PDBj:7ewa
PDBsum7ewa
PubMed35075146
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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