Structure of PDB 7ew9 Chain A

Receptor sequence
>7ew9A (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQI
KRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQ
GVDDAFYTLVREIRKHKE
3D structure
PDB7ew9 KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge.
ChainA
Resolution2.13 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 05C A D12 G60 E62 Y64 R68 D69 M72 D92 H95 Y96 Q99 R102 V103 D12 G60 E62 Y64 R68 D69 M72 D92 H95 Y96 Q99 R102 V103
BS02 GDP A G13 V14 G15 K16 S17 A18 F28 D30 N116 K117 D119 L120 S145 A146 G13 V14 G15 K16 S17 A18 F28 D30 N116 K117 D119 L120 S145 A146
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:7ew9, PDBe:7ew9, PDBj:7ew9
PDBsum7ew9
PubMed35075146
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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