Structure of PDB 7ev3 Chain A

Receptor sequence
>7ev3A (length=319) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
TGSRRIFSGVQPTSDSLHLGNALGAVAQWVGLQDDHDAFFCVVDLHAITI
PQDPEALRRRTLITAAQYLALGIDPGRATIFVQSQVPAHTQLAWVLGCFT
GFGQASRMTTTVGLFTYPVLQAADVLAYDTELVPVGEDQRQHLELARDVA
QRFNSRFPGTLVVPDVLIPKMTAKIYDLQDPTSKMSKSAGTDAGLINLLD
DPALSAKKIRSAVTDSERDIRYDPDVKPGVSNLLNIQSAVTGTDIDVLVD
GYAGHGYGDLKKDTAEAVVEFVNPIQARVDELTADPAELEAVLAAGAQRA
HDVASKTVQRVYDRLGFLL
3D structure
PDB7ev3 Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents.
ChainA
Resolution2.7 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 6.1.1.2: tryptophan--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A V14 Q15 T17 H22 G24 N25 V152 G153 D155 Q156 K191 I192 K201 M202 K204 V10 Q11 T13 H18 G20 N21 V135 G136 D138 Q139 K174 I175 K184 M185 K187
BS02 JE3 A F11 G13 Q15 H50 Y134 Q138 Q156 F7 G9 Q11 H46 Y117 Q121 Q139
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004830 tryptophan-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006436 tryptophanyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ev3, PDBe:7ev3, PDBj:7ev3
PDBsum7ev3
PubMed34908399
UniProtP9WFT3|SYW_MYCTU Tryptophan--tRNA ligase (Gene Name=trpS)

[Back to BioLiP]