Structure of PDB 7ev2 Chain A

Receptor sequence
>7ev2A (length=322) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
GSRRIFSGVQPTSDSLHLGNALGAVAQWVGLQDDHDAFFCVVDLHAITIP
QDPEALRRRTLITAAQYLALGIDPGRATIFVQSQVPAHTQLAWVLGCFTG
FGQASRMTQFKATTVGLFTYPVLQAADVLAYDTELVPVGEDQRQHLELAR
DVAQRFNSRFPGTLVVPDVLIPKMTAKIYDLQDPTSKMSKSAGTDAGLIN
LLDDPALSAKKIRSAVTDSERDIRYDPDVKPGVSNLLNIQSAVTGTDIDV
LVDGYAGHGYGDLKKDTAEAVVEFVNPIQARVDELTADPAELEAVLAAGA
QRAHDVASKTVQRVYDRLGFLL
3D structure
PDB7ev2 Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.2: tryptophan--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A V14 Q15 H22 G24 N25 V152 G153 D155 Q156 K191 I192 K201 M202 K204 V9 Q10 H17 G19 N20 V138 G139 D141 Q142 K177 I178 K187 M188 K190
BS02 JE0 A F11 Q15 H50 Y134 Q138 V152 Q156 F6 Q10 H45 Y120 Q124 V138 Q142
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004830 tryptophan-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006436 tryptophanyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ev2, PDBe:7ev2, PDBj:7ev2
PDBsum7ev2
PubMed34908399
UniProtP9WFT3|SYW_MYCTU Tryptophan--tRNA ligase (Gene Name=trpS)

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