Structure of PDB 7etk Chain A

Receptor sequence
>7etkA (length=284) Species: 746128 (Aspergillus fumigatus) [Search protein sequence]
KPQLQRLAADADVDRMCRLLEEDGAFILKGLLPFDVVESFNRELDVQMAI
PPPKGERLLADKYPPHFKYVPNVATTCPTFRNTVLINPVIHAICEAYFQR
TGDYWLSAAFLREIESGMPAQPFHRDDATHPLMHYQPLEAPPVSLSVIFP
LTEFTEENGATEVILGSHRWTEVGTPERDQAVLATMDPGDVLIVRQRVVH
AGGGNRTTAGKPRRVVLAYFNSVQLTPFETYRTMPREMVESMTVLGQRML
GWRTMKPSDPNIVGINLIDDKRLENVLQLKAADS
3D structure
PDB7etk Structural Insight into the Catalytic Mechanism of the Endoperoxide Synthase FtmOx1.
ChainA
Resolution1.22027 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.38: verruculogen synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AKG A R117 Q126 H129 T166 H205 G207 R218 V220 R112 Q121 H124 T161 H200 G202 R213 V215
BS02 FE2 A H129 D131 H205 H124 D126 H200
BS03 4Q1 A Y68 F72 Y74 F115 R117 Q126 P127 H129 A133 F233 Y63 F67 Y69 F110 R112 Q121 P122 H124 A128 F228
Gene Ontology
Molecular Function
GO:0051213 dioxygenase activity
Biological Process
GO:1902181 verruculogen biosynthetic process
Cellular Component
GO:0005575 cellular_component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7etk, PDBe:7etk, PDBj:7etk
PDBsum7etk
PubMed34796596
UniProtQ4WAW9|FTMF_ASPFU Verruculogen synthase (Gene Name=ftmOx1)

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