Structure of PDB 7eou Chain A

Receptor sequence
>7eouA (length=759) Species: 9606 (Homo sapiens) [Search protein sequence]
LNIAVMLGHSHDVTERELRTLWGPEQAAGLPLDVNVVALLMNRTDPKSLI
THVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILGIHGGASM
IMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREF
ISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSK
DEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDD
WDYSLEARVRDGIGILTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHT
LHPFMVNVTWDGKDLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENHTL
SLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNT
VPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNG
KHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGI
SVMVSRSNFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPSFTIGKAIW
LLWGLVFNNSTTSKIMVSVWAFFAVIFLASYTANLAAFMIQQVTGLSDKK
FQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVS
LKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGS
PWKRQIDLALLQFVGDGEMEELETCWLTGICHNEDIDNMAGVFYMLAAAM
ALSLITFIW
3D structure
PDB7eou Gating mechanism and a modulatory niche of human GluN1-GluN2A NMDA receptors.
ChainA
Resolution4.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6RM A V526 P527 F528 V529 E530 T758 T759 V493 P494 F495 V496 E497 T689 T690 BindingDB: EC50=382nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:7eou, PDBe:7eou, PDBj:7eou
PDBsum7eou
PubMed34186027
UniProtQ12879|NMDE1_HUMAN Glutamate receptor ionotropic, NMDA 2A (Gene Name=GRIN2A)

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