Structure of PDB 7eo2 Chain A

Receptor sequence
>7eo2A (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]
VNYDIIVRHYNYTGKLKLTSVVFILICCFIILENIFVLLTIWKTKKFHRP
MYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALS
ASVWSLLAIAIERYITMLKMKLHNFRLFLLISACWVISLILGGLPIMGWN
CISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSR
RLTFKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEY
FLVLAVLNSGTNPIIYTLTNKEMRRAFIRI
3D structure
PDB7eo2 Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism.
ChainA
Resolution2.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 J89 A Y29 E121 M124 Y10 E92 M95 BindingDB: IC50=0.28nM,EC50=0.37nM,Ki=4.1nM
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0038036 sphingosine-1-phosphate receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7eo2, PDBe:7eo2, PDBj:7eo2
PDBsum7eo2
PubMed34937912
UniProtP21453|S1PR1_HUMAN Sphingosine 1-phosphate receptor 1 (Gene Name=S1PR1)

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