Structure of PDB 7ens Chain A

Receptor sequence
>7ensA (length=330) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
SRRIFSGVQPTSDSLHLGNALGAVAQWVGLQDDHDAFFCVVDLHAITIPQ
DPEALRRRTLITAAQYLALGIDPGRATIFVQSQVPAHTQLAWVLGCFTGF
GQASRMTQFKDKSARQGSEATTVGLFTYPVLQAADVLAYDTELVPVGEDQ
RQHLELARDVAQRFNSRFPGTLVVPDVLIPKMTAKIYDLQDPTSKMSKSA
GTDAGLINLLDDPALSAKKIRSAVTDSERDIRYDPDVKPGVSNLLNIQSA
VTGTDIDVLVDGYAGHGYGDLKKDTAEAVVEFVNPIQARVDELTADPAEL
EAVLAAGAQRAHDVASKTVQRVYDRLGFLL
3D structure
PDB7ens Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.2: tryptophan--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A V14 Q15 T17 H22 G24 N25 G28 V152 G153 D155 Q156 I192 K201 M202 K204 V8 Q9 T11 H16 G18 N19 G22 V146 G147 D149 Q150 I186 K195 M196 K198
BS02 5BX A F11 Q15 H50 Y134 Q138 Q156 F5 Q9 H44 Y128 Q132 Q150
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004830 tryptophan-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006436 tryptophanyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ens, PDBe:7ens, PDBj:7ens
PDBsum7ens
PubMed34908399
UniProtP9WFT3|SYW_MYCTU Tryptophan--tRNA ligase (Gene Name=trpS)

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