Structure of PDB 7elt Chain A

Receptor sequence
>7eltA (length=330) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
SRRIFSGVQPTSDSLHLGNALGAVAQWVGLQDDHDAFFCVVDLHAITIPQ
DPEALRRRTLITAAQYLALGIDPGRATIFVQSQVPAHTQLAWVLGCFTGF
GQASRMTQFKDKSARQGSEATTVGLFTYPVLQAADVLAYDTELVPVGEDQ
RQHLELARDVAQRFNSRFPGTLVVPDVLIPKMTAKIYDLQDPTSKMSKSA
GTDAGLINLLDDPALSAKKIRSAVTDSERDIRYDPDVKPGVSNLLNIQSA
VTGTDIDVLVDGYAGHGYGDLKKDTAEAVVEFVNPIQARVDELTADPAEL
EAVLAAGAQRAHDVASKTVQRVYDRLGFLL
3D structure
PDB7elt Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents.
ChainA
Resolution1.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 6.1.1.2: tryptophan--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TYM A F11 G13 V14 Q15 G24 N25 A29 V47 H50 Y134 Q138 D141 V142 V152 G153 D155 Q156 A190 K191 I192 M202 F5 G7 V8 Q9 G18 N19 A23 V41 H44 Y128 Q132 D135 V136 V146 G147 D149 Q150 A184 K185 I186 M196
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004830 tryptophan-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006436 tryptophanyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7elt, PDBe:7elt, PDBj:7elt
PDBsum7elt
PubMed34908399
UniProtP9WFT3|SYW_MYCTU Tryptophan--tRNA ligase (Gene Name=trpS)

[Back to BioLiP]