Structure of PDB 7ela Chain A

Receptor sequence
>7elaA (length=1402) [Search protein sequence]
MEEDIACVKDLVSKYLANNERLSRQKLAFLVQTEPRMLLMEGLKLLSLCI
EVDSCNANGCEHNSEDKSVERILHDHGVLTPSLCFVVPDGYKLTGNVLIL
LECFVRSSPANFEQKYVEDFKKLEQLKEDLKSVDINLIPLIDGRTSFYNE
QIPDWVNDKLRDTLFSLLKYAQESNSLFEESEYSRLCESLSMTESLNALL
DNRSNHYEEVIASCHQGINNKLTAHEVKLQIEEEYQVFRNRLRKGEIEGQ
FLKVEKNQLLNEFNNLYADKVAEKDSVEHLTHQFKRASPILRFLYANISE
CQMQCWRSFLNKVKSMRILNTRRKLLLIFDALILLASKHDQVRKKPLRGW
LGTCFVSVNDRLVSLESTKKDLKKWVERRQQVECPSKNQILNSIFQKTIS
KATTALRDVGISVDHYKIDMEVICPDGYDLIMDFDVSGVTPTISYQRSEE
EAFPYIMGDVDLLKTTDLERLSSLSLALVNSMKTSSTVKEAYCQEFSLGE
TEFQLIYQKTGECSKCYAINDNRVGEVCSFYADPKRYFPAIFSAEVLQTT
VSTMISWIEDCNELEEQLDKIRSLTKMILILILAHPSKRSQKLLQNLRYF
IMAYVSDYYHKDLIDKVREELITDVEFLLYRLLRTLMGLVLSEDVKSMMT
NRFKFILNISYMCHFITKETPDRLTDQIKCFEKFLEPKVKFGHVSINPAD
TATEEELDDMVYNAKKFLSKGGCTSAKGPSYKKPGVSKKYLSLLTSSFNN
GSLFKQESPQSYNSVGPDTGRLKFSLSYKEQVGGNRELYIGDLRTKMFTR
LIEDYFEALSSQLSGSCLNNEKEFENAILSMKLNVSMAHVSYSMDHSKWG
PMMCPFLFLTVLQNLIFLSIKGRDYLSTLLMWHMHKMVEIPFNVVSAMMK
SFIKAQLGTKQSITEDFFYSNFQIGVVPSHISSILDMGQGILHNTSDFYA
LITERFINYAISCVCGGTIDAYTSSDDQISLFDQTLTELLHRDPEEFRAL
MEFHYYMSDQLNKFVSPKSVIGRFVAEFKSRFFVWGDEVPLLTKFVAAAL
HNIKCKEPHQLAETIDTIVDQSVANGVPVHLCNLIQIRTLSLLQYARYPI
DPFLLNCETDVRDWVDGNRSYRIMRQIEGLIPDACSKIRSMLRRLYNRLK
TGQLHEEFTTNYLSSEHLSSLKNLCELLGVEPPSESDLEYSWLNLAAHHP
LRMVIPTIVKTIQNSSIASGFVGLCRTLGSKCVRGPNKENLYIKSIQSLI
TGTQGIELLTNSIGVQYWRVPLGLRNKSESVVSYFRPLLWDYMCISLSTA
IELGAWVLGDPKTTNPCDYFPLKPTASKLLEDRVGLNHIIHSLRRLYPSV
FEKHILIKFLDLCVALDVNCEALSLVSHIVKWKREEHYIVLSSELRFSHT
RT
3D structure
PDB7ela Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals.
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A S327 N330 K331 S334 D379 L504 K511 T512 Y1452 R1454 R1624 G1627 S1628 S308 N311 K312 S315 D360 L476 K483 T484 Y1095 R1097 R1226 G1229 S1230
BS02 MN A D1192 D1334 E1384 D845 D977 E1027
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016787 hydrolase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ela, PDBe:7ela, PDBj:7ela
PDBsum7ela
PubMed34127846
UniProtA0A097F4L1

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