Structure of PDB 7eiw Chain A

Receptor sequence
>7eiwA (length=468) Species: 9606 (Homo sapiens) [Search protein sequence]
MEPEEYRERGREMVDYICQYLSTVRERRVTPDVQPGYLRAQLPESAPEDP
DSWDSIFGDIERIIMPGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINC
LGFTWASSPACTELEMNVMDWLAKMLGLPEHFLHHHPSSQGGGVLQSTVS
ESTLIALLAARKNKILEMKTSEPDADESSLNARLVAYASDQAHSSVEKAG
LISLVKMKFLPVDDNFSLRGEALQKAIEEDKQRGLVPVFVCATLGTTGVC
AFDCLSELGPICAREGLWLHIDAAYAGTAFLCPEFRGFLKGIEYADSFTF
NPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPGVATDFMHWQIPLSRRFRS
VKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDPSFEIPAKRHLGLV
VFRLKGPNSLTENVLKEIAKAGRLFLIPATIQDKLIIRFTVTSQFTTRDD
ILRDWNLIRDAATLILSQ
3D structure
PDB7eiw Structural analysis of the HDC Y334F mutant
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.22: histidine decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A Y81 T149 V150 S151 H194 T248 D273 A275 K305 Y80 T148 V149 S150 H193 T247 D272 A274 K304
Gene Ontology
Molecular Function
GO:0016830 carbon-carbon lyase activity
GO:0016831 carboxy-lyase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006520 amino acid metabolic process
GO:0019752 carboxylic acid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7eiw, PDBe:7eiw, PDBj:7eiw
PDBsum7eiw
PubMed
UniProtP19113|DCHS_HUMAN Histidine decarboxylase (Gene Name=HDC)

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