Structure of PDB 7ehl Chain A

Receptor sequence
>7ehlA (length=563) Species: 9606 (Homo sapiens) [Search protein sequence]
FNWKLFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTR
DMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLL
RQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVS
LSMLTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEA
LGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFN
CMVLGTLFIGGSLVAGQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRG
LSAGARVFEYMALNPCIPLSGRGSVTFQNVCFSYPCRPGFEVLKDFTLTL
PPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLR
GQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSF
PEGYNTVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESER
VVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLK
KGGLYAELIRRQA
3D structure
PDB7ehl Cryo-EM structure of human ABCB8 transporter in nucleotide binding state.
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR A L294 L305 G397 L411 F414 L157 L168 G260 L273 F276
BS02 ANP A Y481 G512 K513 T514 T515 Y334 G365 K366 T367 T368
BS03 CLR A R275 R423 R139 R285
BS04 CLR A G309 Q422 G172 Q284
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015440 ABC-type peptide transporter activity
GO:0016887 ATP hydrolysis activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006813 potassium ion transport
GO:0006884 cell volume homeostasis
GO:0015833 peptide transport
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
GO:0140141 mitochondrial potassium ion transmembrane transport
Cellular Component
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0031966 mitochondrial membrane
GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:0062157 mitochondrial ATP-gated potassium channel complex

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Cellular Component
External links
PDB RCSB:7ehl, PDBe:7ehl, PDBj:7ehl
PDBsum7ehl
PubMed33872987
UniProtQ9NUT2|MITOS_HUMAN Mitochondrial potassium channel ATP-binding subunit (Gene Name=ABCB8)

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