Structure of PDB 7egu Chain A

Receptor sequence
>7eguA (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
TYLSHFNPRDYLEKYYKFGSAESQILKHLLKNLFKIFCLDGVKGDLLIDI
GSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPAAFDWSPVVT
YVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLS
TLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFS
SLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARKL
3D structure
PDB7egu Macrocyclic Peptides as a Novel Class of NNMT Inhibitors: A SAR Study Aimed at Inhibitory Activity in the Cell.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.1: nicotinamide N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H14 F15 Y20 Y24 E34 I37 G63 S64 G65 T67 Q70 D85 Y86 S87 N90 D142 V143 T163 L164 C165 D167 Y203 M205 Y242 H5 F6 Y11 Y15 E22 I25 G51 S52 G53 T55 Q58 D73 Y74 S75 N78 D130 V131 T151 L152 C153 D155 Y191 M193 Y230
Gene Ontology
Molecular Function
GO:0008112 nicotinamide N-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0030760 pyridine N-methyltransferase activity
Biological Process
GO:0006769 nicotinamide metabolic process
GO:0009410 response to xenobiotic stimulus
GO:0031100 animal organ regeneration
GO:0032259 methylation
GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway
GO:0045722 positive regulation of gluconeogenesis
GO:0090312 positive regulation of protein deacetylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7egu, PDBe:7egu, PDBj:7egu
PDBsum7egu
PubMed34267879
UniProtP40261|NNMT_HUMAN Nicotinamide N-methyltransferase (Gene Name=NNMT)

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