Structure of PDB 7egp Chain A

Receptor sequence

>7egpA (length=750) Species: 559292 (Saccharomyces cerevisiae S288C)

VGIDTHTATDIYQTLIALNLDTTVNDCLDKLLNDECTESTRENALYDYYA
LQLLPLQKAVRGHVLQFEWHQNSLLTNTHPNFLSKIRNINVQDALLTNQL
YKNHELLKLERKKTEAVARLKSMNKSAINQYNRRQDKKNKRLKFGHRLIA
THTNLERDEQKRAEKKAKERLQALLLDQTKDTRITHLLRQTNAFLDYYNV
AHRIKEDIKKQPSILVGGTLKDYQIKGLQWMVSLFNNHLNGILADEMGLG
KTIQTISLLTYLYEMKNIRGPYLVIVPLSTLSNWSSEFAKWAPTLRTISF
KGSPNERKAKQAKIRAGEFDVVLTTFEYIIKERALLSKVKWVHMIIDEGH
RMKNAQSKLSLTLNTHYHADYRLILTGTPLQNNLPELWALLNFVLPKIFN
SVKSFDEWFNTPFDKIELSEEETLLVIRRLHKVLRPFLLRRLKKDVEKEL
PDKVEKVVKCKMSALQQIMYQQMLKYRGFNNQIMQLKKICNHPFVFEEVE
DQINPTRETNDDIWRVAGKFELLDRILPKLKATGHRVLIFFQMTQIMDIM
EDFLRYINIKYLRLDGHTKSDERSELLRLFNAPDSEYLCFILSTRAGGLG
LNLQTADTVIIFDTDWNPHQDLQAQDRAHRIGQKNEVRILRLITTNSVEE
VILERAYKKLDIDGKVIQAGKFDNKSTSEEQEALLRSLLDAEEERRKKRE
EELKDSEINEILARNDEEMAVLTRMDEDRSKKEKSRLREESESAAVYNGR

3D structure

• PDB: 7egp Structure of the SWI/SNF complex bound to the nucleosome and insights into the functional modularity.
• Chain: A
• Resolution: 6.9 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	L825 E874 Y875 F1048 N1049 M1112 G1135 H1136 K1138 R1164 A1165	L278 E327 Y328 F479 N480 M543 G566 H567 K569 R595 A596
BS02	dna	A	R880 R898 N901 S904 K905 R1164	R333 R351 N354 S357 K358 R595
BS03	ADP	A	T766 K768 Y770 G795 K798 T799 I800 N1171 Q1173 I1200	T219 K221 Y223 G248 K251 T252 I253 N602 Q604 I631
BS04	BEF	A	M794 R1196 R1199	M247 R627 R630

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0042393 histone binding
• GO:0140658 ATP-dependent chromatin remodeler activity

External links

• PDB: RCSB:7egp, PDBe:7egp, PDBj:7egp
• PDBsum: 7egp
• PubMed: 33907182
• UniProt: P22082|SNF2_YEAST Transcription regulatory protein SNF2 (Gene Name=SNF2)