Structure of PDB 7edd Chain A

Receptor sequence

>7eddA (length=1394) Species: 1314 (Streptococcus pyogenes)

ASLPPVNTDIHDWVKTKGAWDKGYKGQGKVVAVIDTGIDPAHQSMRISDV
STAKVKSKEDMLARQKAAGINYGSWINDKVVFAHNYVENSDNIKENQKYE
SHGMHVTGIVAGNSKEAAATGERFLGIAPEAQVMFMRVFANDVMGSAESL
FIKAIEDAVALGADVINLSLGTANGAQLSGSKPLMEAIEKAKKAGVSVVV
AAGNERVYGSDHDDPLATNPDYGLVGSPSTGRTPTSVAAINSKWVIQRLM
TVEELEKRADLNHGKAIYSESVDFKNIKDSLGYDKSHQFAYVKESTDAGY
NAQDVKGKIALIERDPNKTYDEMIALAKKHGALGVLIFNNKPGQSNRSMN
GMGIPSAFISHEFGKAMSQLNGNGTGSLEFDSVVSKAPSQKGNEMNHFSN
WGLTSDGYLKPDITAPGGDIYSTYNDNHYGSQTGTSMASPQIAGASLLVK
QYLEKTQPNLPKEKIADIVKNLLMSNAQIHVNPETKTTTSPRQQGAGLLN
IDGAVTSGLYVTGKDNYGSISLGNITDTMTFDVTVHNLSNKDKTLRYDTE
LLTDHVDPQKGRFTLTSRSLKTYQGGEVTVPANGKVTVRVTMDVSQFTKE
LTKQMPNGYYLEGFVRFRDSQDDQLNRVNIPFVGFKGQFENLAVAEESIY
RLKSQGKTGFYFDESGPKDDIYVGKHFTGLVTLGSETNVSTKTISDNGLH
TLGTFKNADGKFILEKNAQGNPVLAISPNGDNNQDFAAFKGVFLRKYQGL
KASVYHASDKEHKNPLWVSPESFKGDKNFNSDIRFAKSTTLLGTAFSGKS
LTGAELPDGYYHYVVSYYPDVVGAKRQEMTFDMILDRQKPVLSQATFDPE
TNRFKPEPLKDRGLAGVRKDSVFYLERKDNKPYTVTINDSYKYVSVEDNK
TFVERQADGSFILPLDKAKLGDFYYMVEDFAGNVAIAKLGDHLPQTLGKT
PIKLKLTDGNYQTKETLKDNLEMTQSDTGLVTNQAQLAVVHRNQPQSQLT
KMNQDFFISPNEDGNKDFVAFKGLENNVYNDLTVNVYAKDDHQKQTPIWS
SQAGAGASAIESTAWYGITARGSKVMPGDYQYVVTYRDEHGKEHQKQYTI
SVNDKKPMITQGRFDTINGVDHFTPDKTKALGSSGIVREEVFYLAKKNGR
KFDVTEGKDGITVSDNKVYIPKNPDGSYTISKRDGVTLSDYYYLVEDRAG
NVSFATLRDLKAVGKDKAVVNFGLDLPVPEDKQIVNFTYLVRDADGKPIE
NLEYYNNSGNSLILPYGKYTVELLTYDTNAAKLESDKIVSFTLSADNNFQ
QVTFKMTMLATSQITAHFDHLLPEGSRVSLKTAQGQLIPLEQSLYVPKAY
GKTVQEGTYEVVVSLPKGYRIEGNTKVNTLPNEVHELSLRLVKV

3D structure

• PDB: 7edd The Autocatalytic Cleavage Domain Is Not Required for the Activity of ScpC, a Virulence Protease from Streptococcus pyogenes : A Structural Insight.
• Chain: A
• Resolution: 2.897 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.110: C5a peptidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	K1050 F1083 E1109	K869 F902 E928
BS02	CA	A	D1017 Q1019 D1042 R1043 D1110	D836 Q838 D861 R862 D929
BS03	CA	A	S908 N910 D912 N914 D916	S727 N729 D731 N733 D735
BS04	CA	A	Q819 E821	Q638 E640
BS05	CA	A	S160 F301 T604 Y610	S44 F124 T423 Y429
BS06	CA	A	S1190 N1192 D1194 N1196 D1198	S1009 N1011 D1013 N1015 D1017
BS07	CA	A	G1004 H1498	G823 H1317

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005618 cell wall
• GO:0016020 membrane

External links

• PDB: RCSB:7edd, PDBe:7edd, PDBj:7edd
• PDBsum: 7edd
• PubMed: 33929828
• UniProt: Q3HV58