Structure of PDB 7ea9 Chain A

Receptor sequence
>7ea9A (length=502) Species: 9606 (Homo sapiens) [Search protein sequence]
VDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDH
LTDITLKVAGRIHAKRASGGKLIFHDLRGEGVKLQVMANSRNYKSEEEFI
HINNKLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHGLKDK
ETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNI
IPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFR
NEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSYKVTY
HPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKIL
DDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLA
KWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGD
DEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAM
KP
3D structure
PDB7ea9 Structural analyses of a human lysyl-tRNA synthetase mutant associated with autosomal recessive nonsyndromic hearing impairment.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
6.1.1.6: lysine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KAA A E301 R323 T330 H331 N332 F335 E339 Y341 E494 I495 N497 Y499 E501 G546 G548 G550 R553 E228 R250 T257 H258 N259 F262 E266 Y268 E421 I422 N424 Y426 E428 G473 G475 G477 R480
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004824 lysine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006430 lysyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Biological Process
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Cellular Component
External links
PDB RCSB:7ea9, PDBe:7ea9, PDBj:7ea9
PDBsum7ea9
PubMed33784510
UniProtQ15046|SYK_HUMAN Lysine--tRNA ligase (Gene Name=KARS1)

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