Structure of PDB 7ea8 Chain A

Receptor sequence
>7ea8A (length=101) Species: 9606 (Homo sapiens) [Search protein sequence]
GGVMKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDL
RFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRG
E
3D structure
PDB7ea8 Cryo-EM structure of SETD2/Set2 methyltransferase bound to a nucleosome containing oncohistone mutations.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R72 R83 F84 T118 R40 R51 F52 T86
BS02 dna A R40 P43 V46 R63 R83 R8 P11 V14 R31 R51
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0030527 structural constituent of chromatin
Cellular Component
GO:0000786 nucleosome

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Molecular Function
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Cellular Component
External links
PDB RCSB:7ea8, PDBe:7ea8, PDBj:7ea8
PDBsum7ea8
PubMed33972509
UniProtQ6PI79|H33_XENLA Histone H3.3

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