Structure of PDB 7e9l Chain A

Receptor sequence
>7e9lA (length=524) Species: 9913 (Bos taurus) [Search protein sequence]
RIDYPKALQILTEGGTHMVCTGRTHTDRLCRFKWLCYSSEAEEFIFFHGN
ASVMLPSLGSRRFQPALLDLSTVEDHNTQYFNFVELPAAALRFMPKPVFV
PDVALIANRFNPDNLMHVFHDDLLPLFYTLRQFPGLAREARLFFMEGWGE
GAHFDLYKLLSPKQPLLRAQLKALGRLLCFSHAFVGLSKVTTWYQYGFVQ
PQGPKANILVSGNEIRQFAHFLMEKLNVSEEYILVFSRTQNRLILNEAEL
LLALAQEFQMKTVTVSLEDHAFADVVRLVSNASMLVSMHGAQLVTALFLP
RGAAVVELFPYAVNPDHYTPYKTLATLPGMDLQYIAWQNTMPENTVTHPE
RPWDQGGIAHLDRAEQARILQSREVPRHLCCRNPEWLFRIYQDTKVDIPS
LIQTIRRVVKGHPGPRKQKWTVSLYPGKVREARCQASVQGASEARLSVSW
QIPWNLKYLKVREVKYEVWLQEQGENTYVPYMLALQNHTFTENIKPFTTY
LVWIRCIFNKTLLGPFADVLVCST
3D structure
PDB7e9l The structure of POMGNT2 provides new insights into the mechanism to determine the functional O-mannosylation site on alpha-dystroglycan.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.312: protein O-mannose beta-1,4-N-acetylglucosaminyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H125 N126 F159 N160 F247 R438 H76 N77 F110 N111 F198 R382
BS02 UDP A N163 L164 R294 Q296 N297 R298 E324 G346 A347 Y447 N114 L115 R238 Q240 N241 R242 E268 G290 A291 Y391
BS03 MAN A H166 C436 H117 C380
Gene Ontology
Molecular Function
GO:0008375 acetylglucosaminyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0097363 protein O-acetylglucosaminyltransferase activity
Biological Process
GO:0001764 neuron migration
GO:0006486 protein glycosylation
GO:0006493 protein O-linked glycosylation
GO:0035269 protein O-linked mannosylation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7e9l, PDBe:7e9l, PDBj:7e9l
PDBsum7e9l
PubMed33893702
UniProtQ5NDF2|PMGT2_BOVIN Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (Gene Name=POMGNT2)

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