Structure of PDB 7e6t Chain A

Receptor sequence
>7e6tA (length=796) Species: 9606 (Homo sapiens) [Search protein sequence]
PDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWL
QAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKID
SLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSS
RLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRP
GIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFS
SGPDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFA
LKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLRPLCTGDENIS
SVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADI
KKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGS
IVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRK
GIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKE
IEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSY
LLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRV
LLVFEANLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITC
HEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFF
IVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIIL
3D structure
PDB7e6t Structural insights into the activation of human calcium-sensing receptor.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A S170 D190 Y489 S149 D169 Y437
BS02 CA A T100 N102 T79 N81
BS03 TCR A R66 S147 A168 Y218 E297 R45 S126 A147 Y197 E276
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7e6t, PDBe:7e6t, PDBj:7e6t
PDBsum7e6t
PubMed34467854
UniProtP41180|CASR_HUMAN Extracellular calcium-sensing receptor (Gene Name=CASR)

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