Structure of PDB 7e6e Chain A

Receptor sequence
>7e6eA (length=412) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168) [Search protein sequence]
HMNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKYYNQYN
SNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMV
ALSYARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGT
ISLEDVRETVTSNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDG
AQSTPHMKIDVQDLDCDFFALSSHKMCGPTGVGVLYGKKALLENMEPAEF
GGEMIDFVGLYESTWKELPWKFEAGTPIIAGAIGLGAAIDFLEEIGLDEI
SRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTFNLDDVHPHDVATVLD
AEGIAVRAGHHCAQPLMKWLDVTATAAASFYLYNTEEEIDKLVEALQKTK
EYFTNVFVDLEH
3D structure
PDB7e6e Cycloserine enantiomers inhibit PLP-dependent cysteine desulfurase SufS via distinct mechanisms.
ChainA
Resolution2.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.8.1.7: cysteine desulfurase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PMP A T93 H121 D198 A200 S221 H223 K224 T94 H122 D199 A201 S222 H224 K225
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0030170 pyridoxal phosphate binding
GO:0031071 cysteine desulfurase activity
Biological Process
GO:0006534 cysteine metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7e6e, PDBe:7e6e, PDBj:7e6e
PDBsum7e6e
PubMed35395703
UniProtO32164|SUFS_BACSU Cysteine desulfurase SufS (Gene Name=sufS)

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