Structure of PDB 7e6c Chain A

Receptor sequence
>7e6cA (length=413) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168) [Search protein sequence]
HMNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKYYNQYN
SNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMV
ALSYARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGT
ISLEDVRETVTSNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDG
AQSTPHMKIDVQDLDCDFFALSSHKMCGPTGVGVLYGKKALLENMEPAEF
GGEMIDFVGLYESTWKELPWKFEAGTPIIAGAIGLGAAIDFLEEIGLDEI
SRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTFNLDDVHPHDVATVLD
AEGIAVRAGHHAAQPLMKWLDVTATARASFYLYNTEEEIDKLVEALQKTK
EYFTNVFVDLEHH
3D structure
PDB7e6c Cycloserine enantiomers inhibit PLP-dependent cysteine desulfurase SufS via distinct mechanisms.
ChainA
Resolution1.73 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.8.1.7: cysteine desulfurase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7TS A A28 A29 T92 T93 H121 N173 D198 A200 S221 H223 K224 R356 R376 A29 A30 T93 T94 H122 N174 D199 A201 S222 H224 K225 R357 R377
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0030170 pyridoxal phosphate binding
GO:0031071 cysteine desulfurase activity
Biological Process
GO:0006534 cysteine metabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7e6c, PDBe:7e6c, PDBj:7e6c
PDBsum7e6c
PubMed35395703
UniProtO32164|SUFS_BACSU Cysteine desulfurase SufS (Gene Name=sufS)

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