Structure of PDB 7e5a Chain A

Receptor sequence
>7e5aA (length=465) Species: 9606 (Homo sapiens) [Search protein sequence]
IHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYL
MNKLAGKNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDV
EKADNKNDIQIFALALLLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKA
RNSPEDPADSASFFPDLVWTLRDFCLGLEIDGQLVTPDEYLENSLRPKQG
SDQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKKLAQLETLPDDELEPE
FVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVNAISSGDLPC
IENAVLALAQRENSAAVQKAIAHYDQQMGLPMETLQELLDLHATSEREAI
EVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIF
GPLEEAVKQGIYSNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKES
VSHAILQTDQALTET
3D structure
PDB7e5a Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins.
ChainA
Resolution2.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A R48 G50 K51 S52 Y53 V67 A68 S69 R181 D182 P239 L245 L248 R44 G46 K47 S48 Y49 V63 A64 S65 R172 D173 P230 L236 L239
BS02 AF3 A Y47 R48 K51 H74 T75 G100 Y43 R44 K47 H70 T71 G96
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:7e5a, PDBe:7e5a, PDBj:7e5a
PDBsum7e5a
PubMed33876762
UniProtQ96PP8|GBP5_HUMAN Guanylate-binding protein 5 (Gene Name=GBP5)

[Back to BioLiP]