Structure of PDB 7e3n Chain A

Receptor sequence
>7e3nA (length=401) Species: 185431 (Trypanosoma brucei brucei TREU927) [Search protein sequence]
TGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRV
TVEAAYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGT
VFREPIICSNVPRLVTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRF
IPANGGEPKVYKVFDYKSGGVMMGMYNTDDSIRDFARSCFEFALARKWPL
YLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCGIFYEHRLIDNMVAH
CMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTVEVEA
AHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQ
RLEDVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKV
A
3D structure
PDB7e3n Crystal structure of Isocitrate dehydrogenase from Trypanosoma brucei.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.42: isocitrate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A T75 T77 N96 L287 G288 H308 G309 T310 V311 T312 R313 H314 N327 T69 T71 N90 L281 G282 H302 G303 T304 V305 T306 R307 H308 N321
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004450 isocitrate dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006102 isocitrate metabolic process
GO:0006739 NADP metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0020015 glycosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7e3n, PDBe:7e3n, PDBj:7e3n
PDBsum7e3n
PubMed
UniProtQ387G0

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