Structure of PDB 7e0x Chain A

Receptor sequence

>7e0xA (length=384) Species: 3702 (Arabidopsis thaliana)

KNPKSDKFKVKRFHHIEFWCGDATNVARRFSWGLGMRFSAKSDLSTGNMV
HASYLLTSGDLRFLFTAPYSPSLSAGEIKPTTTASIPSFDHGSCRSFFSS
HGLGVRAVAIEVEDAESAFSISVANGAIPSSPPIVLNEAVTIAEVKLYGD
VVLRYVSYKAEFLPGFERVEDASSFPLDYGIRRLDHAVGNVPELGPALTY
VAGFTGFHQFAEFESGLNWAVLASNDEMVLLPINEPVHGTKRKSQIQTYL
EHNEGAGLQHLALMSEDIFRTLREMRKRSSIGGFDFMPSPPPTYYQNLKK
RVGDVLSDDQIKECEELGILVDRDDQGTLLQIFTKPLGDRPTIFIEIIQR
VGCMMYQSGGCGGFGKGNFSELFKSIEEYEKTLE

3D structure

• PDB: 7e0x Rational Redesign of Enzyme via the Combination of Quantum Mechanics/Molecular Mechanics, Molecular Dynamics, and Structural Biology Study.
• Chain: A
• Resolution: 1.887 Å

Enzymatic activity

• Enzyme Commision number: 1.13.11.27: 4-hydroxyphenylpyruvate dioxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CO	A	H226 H308 E394	H186 H260 E346
BS02	4HP	A	L265 N282 Q293 Q307	L217 N234 Q245 Q259

Gene Ontology

Molecular Function

• GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity
• GO:0005506 iron ion binding
• GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
• GO:0042802 identical protein binding
• GO:0046872 metal ion binding
• GO:0051213 dioxygenase activity

Biological Process

• GO:0006559 L-phenylalanine catabolic process
• GO:0006572 tyrosine catabolic process
• GO:0009072 aromatic amino acid metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7e0x, PDBe:7e0x, PDBj:7e0x
• PDBsum: 7e0x
• PubMed: 34542283
• UniProt: P93836|HPPD_ARATH 4-hydroxyphenylpyruvate dioxygenase (Gene Name=HPD)