Structure of PDB 7dxg Chain A

Receptor sequence

>7dxgA (length=698) Species: 9606 (Homo sapiens) [Search protein sequence]

LSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANE
HLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLDD
FYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKC
NDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELA
VLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQS
GDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAV
KFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLG
LLVMNAADRFEGTLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPK
EYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDNVKYYNLARI
KWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDI
FKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFG
LSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQDA
DVEWKFARAKLWFSYFEEGRTLPVPFNLVPRQYQKIMKRLIKRYVLQAQI
DKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRELGEKL

3D structure

PDB

7dxg Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ZN	A	H249 C258	H144 C153
BS02	CA	A	E144 D890	E50 D668
BS03	Y01	A	Y392 M403 V410 F440 T451 N617	Y287 M298 V305 F335 T346 N483
BS04	HOR	A	H446 E509 D530 R609 Y612 I613 S752 Y753 R758	H341 E390 D411 R475 Y478 I479 S614 Y615 R620
BS05	CA	A	N880 E883	N658 E661
BS06	Y01	A	A535 I594	A416 I460
BS07	Y01	A	F531 A539 I542 M546 S589 I594	F412 A420 I423 M427 S455 I460
BS08	98R	A	F675 F679 W680	F541 F545 W546
BS09	Y01	A	K698 F699 N702 I703 V706	K564 F565 N568 I569 V572
BS10	98R	A	Y705 V713 T714 I717	Y571 V579 T580 I583

Gene Ontology

	Molecular Function
GO:0005216	monoatomic ion channel activity
GO:0005261	monoatomic cation channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0015279	store-operated calcium channel activity
GO:0042803	protein homodimerization activity
GO:0070679	inositol 1,4,5 trisphosphate binding

	Biological Process
GO:0006811	monoatomic ion transport
GO:0006812	monoatomic cation transport
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007338	single fertilization
GO:0032414	positive regulation of ion transmembrane transporter activity
GO:0051480	regulation of cytosolic calcium ion concentration
GO:0051928	positive regulation of calcium ion transport
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport

	Cellular Component
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0034703	cation channel complex
GO:0036057	slit diaphragm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7dxg, PDBe:7dxg, PDBj:7dxg
PDBsum	7dxg
PubMed	35051376
UniProt	Q9Y210\|TRPC6_HUMAN Short transient receptor potential channel 6 (Gene Name=TRPC6)

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