Structure of PDB 7dxb Chain A

Receptor sequence
>7dxbA (length=738) Species: 9606 (Homo sapiens) [Search protein sequence]
GPAFMFNTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQN
ALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPG
FAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVV
HMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAY
LSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDL
CRDSEEVEAILNGDASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLS
GLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAH
AASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEM
LIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFL
AFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISE
GLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFF
AFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYD
HKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFAR
SKLWLSYFDDGKTLPPPFSLVPQPTRYQQIMKRLIKRYVLKAQVDKENDE
VNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKL
3D structure
PDB7dxb Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 A Y323 K337 I382 A547 N548 Y296 K310 I355 A520 N521
BS02 Y01 A A470 T473 I525 A443 T446 I498
BS03 ZN A H178 C182 C184 C187 H164 C168 C170 C173
BS04 CA A E73 D798 E59 D712
BS05 CA A E786 N788 E791 E700 N702 E705
BS06 CA A E440 E443 N458 E413 E416 N431
BS07 98R A Y636 V644 T645 Y609 V617 T618
BS08 98R A F606 F610 F579 F583
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005227 calcium-activated cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0015279 store-operated calcium channel activity
GO:0046872 metal ion binding
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0007338 single fertilization
GO:0007602 phototransduction
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0033198 response to ATP
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051592 response to calcium ion
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:1903244 positive regulation of cardiac muscle hypertrophy in response to stress
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034703 cation channel complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7dxb, PDBe:7dxb, PDBj:7dxb
PDBsum7dxb
PubMed35051376
UniProtQ13507|TRPC3_HUMAN Short transient receptor potential channel 3 (Gene Name=TRPC3)

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