Structure of PDB 7dv6 Chain A

Receptor sequence
>7dv6A (length=304) Species: 9606 (Homo sapiens) [Search protein sequence]
ELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKT
EKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTR
HVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKN
DLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLASAMNLENV
ESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVASMAD
NVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFS
ELEH
3D structure
PDB7dv6 Discovery of Selective Transforming Growth Factor beta Type II Receptor Inhibitors as Antifibrosis Agents.
ChainA
Resolution2.39 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D379 K381 N384 D397 T421
Catalytic site (residue number reindexed from 1) D140 K142 N145 D158 T182
Enzyme Commision number 2.7.11.30: receptor protein serine/threonine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HJF A V250 V258 A275 K277 L305 F327 H328 G331 N332 L386 C396 V11 V19 A36 K38 L66 F88 H89 G92 N93 L147 C157
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7dv6, PDBe:7dv6, PDBj:7dv6
PDBsum7dv6
PubMed34055221
UniProtP37173|TGFR2_HUMAN TGF-beta receptor type-2 (Gene Name=TGFBR2)

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