Structure of PDB 7dua Chain A

Receptor sequence
>7duaA (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
LEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK
ENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGS
LRGFLRESRKVGPGYLGDERALTMGDLISFAWQISQGMQYLAEMKLVHRD
LAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLF
DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPD
NCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVK
3D structure
PDB7dua Selective RET inhibitor TAS0953/HM06
ChainA
Resolution1.64 Å
3D
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HJ0 A L730 G731 V738 A756 K758 E775 V804 A807 S811 L881 D892 L19 G20 V27 A45 K47 E64 V93 A96 S100 L157 D168 BindingDB: IC50=0.170nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7dua, PDBe:7dua, PDBj:7dua
PDBsum7dua
PubMed
UniProtP07949|RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret (Gene Name=RET)

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