Structure of PDB 7du9 Chain A

Receptor sequence
>7du9A (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKEN
ASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLR
GFLRESRKVGPGYLGDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLA
ARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDH
IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNC
SEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVK
3D structure
PDB7du9 Selective RET inhibitor TAS0953/HM06
ChainA
Resolution2.31 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Q4J A L730 G731 G733 G736 K737 V738 A756 K758 M759 E805 Y806 A807 G810 L881 L17 G18 G20 G23 K24 V25 A43 K45 M46 E92 Y93 A94 G97 L155 BindingDB: IC50=6000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7du9, PDBe:7du9, PDBj:7du9
PDBsum7du9
PubMed
UniProtP07949|RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret (Gene Name=RET)

[Back to BioLiP]