Structure of PDB 7du2 Chain A

Receptor sequence
>7du2A (length=1293) Species: 9606 (Homo sapiens) [Search protein sequence]
EQFRETDVAKKISHICFGMKSPEEMRQQAHIQVVSKNLYSQDNQHAPLLY
GVLDHRMGTSEKDRPCETCGKNLADCLGHYGYIDLELPCFHVGYFRAVIG
ILQMICKTCCHIMLSQEEKKQFLDYLKRPGLTYLQKRGLKKKISDKCRKK
NICHHCGAFNGTVKKCGLLKIIHEAQENLNPLVVLNLFKRIPAEDVPLLL
MNPEAGKPSDLILTRLLVPPLCIRPDLTMKLTEIIFLNDVIKKHRISGAK
TQMIMEDWDFLQLQCALYINSELWTRGFVQRLKGKQGRFRGNLSGKRVDF
SGRTVISPDPNLRIDEVAVPVHVAKILTFPEKVNKANINFLRKLVQNGPE
VHPGANFIQQRHTQMKRFLKYGNREKMAQELKYGDIVERHLIDGDVVLFN
RQPSLHKLSIMAHLARVKPHRTFRFNECVCTPYNADFDGDEMNLHLPQTE
EAKAEALVLMGTKANLVTPRNGEPLIAAIQDFLTGAYLLTLKDTFFDRAK
ACQIIASILVGKDEKIKVRLPPPTILKPVTLWTGKQIFSVILRPSDDNPV
RANLRTKGKQYCGKGEDLCANDSYVTIQNSELMSGSMDKGTLGSGSKNNI
FYILLRDWGQNEAADAMSRLARLAPVYLSNRGFSIGIGDVTPGQGLLKAK
YELLNAGYKKCDEYIEALNTGKLQQQPGCTAEETLEALILKELSVIRDHA
GSACLRELDKSNSPLTMALCGSKGSFINISQMIACVGQQAISGSRVPDGF
ENRSLPHFEKHSKLPAAKGFVANSFYSGLTPTEFFFHTMAGREGLVDTAV
KTAETGYMQRRLVKSLEDLCSQYDLTVRSSTGDIIQFIYGGDGLDPAAME
GKDEPLEFKRVLDNIKAVFPCPSEPALSKNELILTTESIMKKSEFLCCQD
SFLQEIKKFIKGVSEKIKKTRDKYGINDNGTTEPRVLYQLDRITPTQVEK
FLETCRDKYMRAQMEPGSAVGALCAQSIGEPGTQMNITLGVPRIKEIINA
SKAISTPIITAQLDKDDDADYARLVKGRIEKTLLGEISEYIEEVFLPDDC
FILVKLSLERIRLLRLEVNAETVRYSICTSKLRVKPGDVAVHGEAVVCVT
PRENSKSSMYYVLQFLKEDLPKVVVQGIPEVSRAVIHIKYKLLVEGDNLR
AVMATHGVKGTRTTSNNTYEVEKTLGIEAARTTIINEIQYTMVNHGMSID
RRHVMLLSDLMTYKGEVLGITRFGLAKMKESVLMLASFEKTADHLFDAAY
FGQKDSVCGVSECIIMGIPMNIGTGLFKLLHKADRDPNPPKRP
3D structure
PDB7du2 Structure of human RNA polymerase III elongation complex.
ChainA
Resolution3.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R353 R360 R366 Q465 T865 Y870 E1322 K1323 R290 R297 R303 Q402 T802 Y807 E1239 K1240
BS02 MG A D499 D501 D503 D436 D438 D440
BS03 ZN A C72 H82 C69 H79
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0032728 positive regulation of interferon-beta production
GO:0042797 tRNA transcription by RNA polymerase III
GO:0045087 innate immune response
GO:0051607 defense response to virus
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0031981 nuclear lumen
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7du2, PDBe:7du2, PDBj:7du2
PDBsum7du2
PubMed33674783
UniProtO14802|RPC1_HUMAN DNA-directed RNA polymerase III subunit RPC1 (Gene Name=POLR3A)

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