Structure of PDB 7drk Chain A

Receptor sequence
>7drkA (length=184) Species: 158879 (Staphylococcus aureus subsp. aureus N315) [Search protein sequence]
NIPNQITVFRVVLIPVFILFALVDFGFGNVSFLGGYEIRIELLISGFIFI
LASLSDFVDGYLARKWNLVTNMGKFLDPLADKLLVASALIVLVQLGLTNS
VVAIIIIAREFAVTGLRLLQIEQGFVSAAGQLGKIKTAVTMVAITWLLLG
DPLATLIGLSLGQILLYIGVIFTILSGIEYFYKG
3D structure
PDB7drk The phosphatidylglycerol phosphate synthase PgsA utilizes a trifurcated amphipathic cavity for catalysis at the membrane-cytosol interface.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.8.5: CDP-diacylglycerol--glycerol-3-phosphate 1-phosphatidyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D57 D60 D78 D56 D59 D77
BS02 ZN A D57 D78 D82 D56 D77 D81
BS03 58A A P4 N5 I51 S54 L55 D57 F58 D60 G61 R65 V70 G74 D78 K135 L166 P3 N4 I50 S53 L54 D56 F57 D59 G60 R64 V69 G73 D77 K134 L165
BS04 G3P A Q164 Y168 Q163 Y167
Gene Ontology
Molecular Function
GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity
GO:0016740 transferase activity
GO:0016780 phosphotransferase activity, for other substituted phosphate groups
Biological Process
GO:0006655 phosphatidylglycerol biosynthetic process
GO:0008654 phospholipid biosynthetic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:7drk, PDBe:7drk, PDBj:7drk
PDBsum7drk
PubMed34901881
UniProtP63756|PGSA_STAAN CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (Gene Name=pgsA)

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