Structure of PDB 7dqv Chain A

Receptor sequence

>7dqvA (length=589) Species: 280699 (Cyanidioschyzon merolae strain 10D)

TTGVTARRIFALAWSSSATMIVIGFIASILEVATLPAFAIVFGRMFQVFT
KSKSQIEGETWKYSVGFVGIGVFEFIVAGSRTALFGIASERLARDLRVAA
FSNLVEQDVTYFDRRKAGELGGKLNNDVQVIQYSFSKLGAVLFNLAQCVV
GIIVAFIFAPALTGVLIALSPLVVLAGAAQMIEMSGNTKRSSEAYASAGS
VAAEVFSNIRTTKAFEAERYETQRYGSKLDPLYRLGRRRYISDGLFFGLS
MLVIFCVYALALWWGGQLIARGSLNLGNLLTAFFSAILGFMGVGQAAQVW
PDVTRGLGAGGELFAMIDRVPQYRRPDPGAEVVTQPLVLKQGIVFENVHF
RYPTRMNVEVLRGISLTIPNGKTVAIVGGSGAGKSTIIQLLMRFYDIEPQ
GGGLLLFDGTPAWNYDFHALRSQIGLVSQEPVLFSGTIRDNILYGKRDAT
DEEVIQALREANAYSFVMALPDGLDTEVGERGLALSGGQKQRIAIARAIL
KHPTLLCLDESTSALDAESEALVQEALDRMMASDGVTSVVIAHRLSTVAR
ADLILVMQDGVVVEQGNHSELMALGPSGFYYQLVEKQLA

3D structure

• PDB: 7dqv The crystal structure of the CmABCB1 G132V mutant, which favors the outward-facing state, reveals the mechanism of the pivotal joint between TM1 and TM3.
• Chain: A
• Resolution: 2.15 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ANP	A	Y452 R455 V460 S480 G483 K484 S485 T486 Q529	Y352 R355 V360 S380 G383 K384 S385 T386 Q429
BS02	DMU	A	G478 G479 G481 H643 L645 Q658 D659	G378 G379 G381 H543 L545 Q558 D559
BS03	DMU	A	F110 W114 F125 L242	F10 W14 F25 L142
BS04	MG	A	S485 Q529	S385 Q429

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0140359 ABC-type transporter activity

Biological Process

• GO:0055085 transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7dqv, PDBe:7dqv, PDBj:7dqv
• PDBsum: 7dqv
• PubMed: 33683740
• UniProt: M1VAN7