Structure of PDB 7dqi Chain A

Receptor sequence
>7dqiA (length=185) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
LDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEIIVTIHA
DNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLGVGVSVVNALSQKLELV
IQREGKIHRQIYEHGVPQAPLAVTGETEKTGTMVRFWPSLETFTNVTEFE
YEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHY
3D structure
PDB7dqi Identification of new building blocks by fragment screening for discovering GyrB inhibitors.
ChainA
Resolution1.91 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AX7 A H147 E174 H114 E141
BS02 HFC A V43 N46 A47 V71 D73 I78 V120 T165 V167 V28 N31 A32 V56 D58 I63 V87 T132 V134
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7dqi, PDBe:7dqi, PDBj:7dqi
PDBsum7dqi
PubMed34098257
UniProtP0AES6|GYRB_ECOLI DNA gyrase subunit B (Gene Name=gyrB)

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