Structure of PDB 7dp5 Chain A

Receptor sequence
>7dp5A (length=287) Species: 6279 (Brugia malayi) [Search protein sequence]
KNEDESKYLDQVRYILKNGERIDDRTGAGTISVFGMHSVYSLRNGVVPVL
TTKRVYWKGVVEELLWFIRGDTNAKHLSEKGVRIWDANGSRQFLDQCGFS
DRSEGDLGPIYGFQWRHCGAEYRGMDTDYTNQGIDQLSEIIDLIKNEPHS
RRIILSAWNVKDLKLMALPPCHTLAQFAVRNGELSCQLYQRSGDMGLGVP
FNLASYGLLTHMIAHVCGLKTGHLCHVLGDAHVYMNHVDALQEQLKRQPR
QFPTVRFIGNIKTIDDFTYESIVLENYQPMPAIKMAM
3D structure
PDB7dp5 Crystallographic investigation and inhibition of Brugia malayi thymidylate synthase by a folate analog
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.45: thymidylate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UMP A R42 C188 R208 S209 D211 G215 N219 H249 Y251 R25 C171 R191 S192 D194 G198 N202 H232 Y234
BS02 MTX A Y73 I101 L214 F218 M302 M304 Y56 I84 L197 F201 M285 M287
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0016741 transferase activity, transferring one-carbon groups
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:7dp5, PDBe:7dp5, PDBj:7dp5
PDBsum7dp5
PubMed
UniProtA0A4E9EZW9

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