Structure of PDB 7doz Chain A

Receptor sequence
>7dozA (length=198) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
PQVTLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMSLPGRWKPKMIGGI
GGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGMTLNFP
QVTLWQRPLVTIKIGGQLKEALLDTGADNTVLEEMSLPGRWKPKMIGGIG
GFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGATLNF
3D structure
PDB7doz Molecular basis for reduced cleavage activity and drug resistance in D30N HIV-1 protease.
ChainA
Resolution1.91 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1UN A D25 G27 G49 I50 I84 D1025 G1027 A1028 D1029 N1030 I1050 P1081 I1084 D25 G27 G49 I50 I84 D124 G126 A127 D128 N129 I149 P180 I183
BS02 1UN A D25 G27 A28 N30 I50 P81 D1025 G1027 G1049 I1050 D25 G27 A28 N30 I50 P81 D124 G126 G148 I149
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7doz, PDBe:7doz, PDBj:7doz
PDBsum7doz
PubMed34609269
UniProtP04585|POL_HV1H2 Gag-Pol polyprotein (Gene Name=gag-pol)

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