Structure of PDB 7dia Chain A

Receptor sequence
>7diaA (length=1072) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
EWIHEKSPKHNSYDIIEKRYNEEFKMTYTVYQHKKAKTQVISLGTNDPLD
VEQAFAFYVKTLTHSGKGIPHILEHSVLSGSKNYNYKNSIGLLEKGTLHT
HLNAYTFNDRTVYMAGSMNNKDFFNIMGVYMDSVFQPNVLENKYIFETEG
WTYEVEKLKEDEKGKAEIPQMKDYKVSFNGIVYNEMKGALSSPLEDLYHE
EMKYMFPDNVHSNNSGGDPKEITNLTYEEFKEFYYKNYNPKKVKVFFFSK
NNPTELLNFVDQYLGQLDYSKYRDDAVESVEYQTYKKGPFYIKKKYGDHS
EEKENLVSVAWLLNPKVDLSLENPTDYFVLLIINNLLIHTPESVLYKALT
DCGLGNNVIDRGLNDSLVQYIFSIGLKGIKRNNEKIKNFDKVHYEVEDVI
MNALKKVVKEGFNKSAVEASINNIEFILKEANLKTSKSIDFVFEMTSKLN
YNRDPLLIFEFEKYLNIVKNKIKNEPMYLEKFVEKHFINNAHRSVILLEG
DENYAQEQENLEKQELKKRIENFNEQEKEQVIKNFEELSKYKNAEESPEH
LNKFPIISISDLNKKTLEVPVNVYFTNINENNNIMETYNKLKTNEHMLKD
NMDVFLKKYVLKKYEGNVPILVYEMPTTGIVYLQFVFSLDHLTVDELAYL
NLFKTLILENKTNKRSSEDFVILREKNIGSMSANVALYSKDDHLNVTDKY
NAQALFNLEMHVLSHKCNDALNIALEAVKESDFSNKKKVIDILKRKINGM
KTTFSEKGYAILMKYVKAHLNSKHYAHNIIYGYENYLKLQEQLELAENDF
KTLENILVRIRNKIFNKKNLMVSVTSDYGALKHLFVNSNESLKNLVSYFE
ENDKYIMGWNEEIKSKKLFDEEKVKKEFFVLPTFVNSVSMSGILFKPGEY
LDPSFTVIVAALKNSYLWDTVRGLNGAYGVFADIEYDGSVVFLSARDPNL
EKTLATFRESAKGLRKMADTMTENDLLRYIINTIGTIDKPRRGIELSKLS
FLRLISNESEQDRVEFRKRIMNTKKEDFYKFADLLESKVNEFEKNIVIIT
TKEKANEYIANVDGEFKKVLIE
3D structure
PDB7dia Protease in complex with inhibitor
ChainA
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 H8O A F82 Y413 I513 D526 F527 E530 I544 F24 Y327 I427 D440 F441 E444 I458
BS02 YMZ A Y868 M872 V1051 F1052 Y759 M763 V930 F931
BS03 ZN A H129 H133 E243 H71 H75 E185
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0016485 protein processing
GO:0042540 hemoglobin catabolic process
Cellular Component
GO:0005773 vacuole
GO:0005774 vacuolar membrane
GO:0016020 membrane
GO:0020011 apicoplast
GO:0020020 food vacuole
GO:0031982 vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7dia, PDBe:7dia, PDBj:7dia
PDBsum7dia
PubMed38593807
UniProtQ76NL8|FCLN_PLAF7 Falcilysin (Gene Name=FLN)

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